Drug Abuse Drug Abuse is generally defined as the use of a drug with such frequency that the user has physical or mental harm or it impairs social abilities. The substances that are discussed in this report are called psychoactive drugs; those drugs that influence or alter the workings of the mind, affect moods, emotions, feelings, and thinking processes. Drug Dependence/Addiction There are three basic characteristics that indicate that the user is dependent on a drug. First, the user continues to use the drug for an extended period of time. Second, the user finds it difficult to stop using the drug. They may drop out of school, steal, go to jail, lose their jobs, or leave their families in orde