Cuba Cuba is the largest island of the West Indies, lying south of Florida and east of Mexico's Yucatán Peninsula. The Republic of Cuba is combined with the surrounding islands. On the East, Cuba is separated from the island of Hispaniola by the Windward Passage. The U.S. maintains a naval base at Guantá namo Bay in the Southeast. The capital and largest city of Cuba is Havana. The island extends about 760 miles from Cabo de San Antonio to Cabo Maisí , the western and eastern extremities. The average width is about 50 miles. The total area is 44,218 square miles including the area of the Isla de la Juventud (Isle of Youth) and of other islands of